Keanu Reeves
(Neo (segment "Kid's Story")),
Carrie-Anne Moss
(Trinity),
Carrie-Anne Moss
(Trinity (segments "Kid's Story" and "A Detective Story")),
Hedy Burress
(Cis),
Hedy Burress
(Cis (segment "Program")),
Tara Strong
(Crew Woman),
Tara Strong
(Crew Woman (segment "Final Flight of the Osiris")),
Melinda Clarke
(Alexa),
Dane A. Davis
(01 Versatran Spokesman),
Dane A. Davis
(01 Versatran Spokesman (segment "The Second Renaissance, Part II")),
John DeMita
(Teacher (segment "Kid's Story")),
Julia Fletcher
(The Instructor),
Julia Fletcher
(The Instructor (segments "The Second Renaissance, Parts I&II")),
Debi Derryberry
(Kid),
Debi Derryberry
(Kid (segment "The Second Renaissance, Part II")),
John DiMaggio
(Crew Man),
John DiMaggio
(Crew Man (segment "Final Flight of the Osiris")),
Jack Fletcher
(Exterminators),
Bette Ford
(Old Woman (segment "Final Flight of the Osiris")),
Rick Gomez
(Pilot (segment "Final Flight of the Osiris")),
Tom Kenny
(Exterminators),
Tom Kenny
(Operator (segment "Final Flight of the Osiris")),
Matt McKenzie
(Agent),
Kevin Michael Richardson
(Agent #2),
Kevin Michael Richardson
(Thadeus (segment "Final Flight of the Osiris")),
Dwight Schultz
(Additional voices),
Dwight Schultz
(Townspeople),
Pamela Adlon
(Jue),
Pamela Adlon
(Jue (segment "Final Flight of the Osiris")),
Jill Talley
(Mother),
Jill Talley
(Mother (segments "The Second Renaissance, Parts I&II")),
James Arnold Taylor
(Additional voices),
James Arnold Taylor
(Ash (segment "A Detective Story")),
Victor Williams
(Dan),
Clayton Watson
(Michael Karl 'The Kid' Popper (segment "Kid's Story")),
Clayton Watson
(Michael Karl Popper (The Kid))