Henry Fonda
(Frank),
Charles Bronson
(Harmonica),
Claudia Cardinale
(Jill McBain),
Jack Elam
(Snaky - Member of Frank's Gang),
Jason Robards
(Manuel 'Cheyenne' Gutiérrez),
Livio Andronico
(Bit part),
Salvatore Basile
(Member of Cheyenne's Gang),
Aldo Berti
(Member of Frank's Gang Playing Poker),
Frank Braña
(Member of Frank's Gang Smoking Pipe at Auction),
Marilù Carteny
(Mourner at Brett McBain's Funeral),
Saturno Cerra
(Member of Frank's Gang on Train),
Gabriele Ferzetti
(Morton - Railroad Baron),
Lionel Stander
(Barman),
Paolo Stoppa
(Sam),
Woody Strode
(Stony - Member of Frank's Gang),
Frank Wolff
(Brett McBain),
Keenan Wynn
(Sheriff - Auctioneer),
Joseph Bradley
(Train Station Master)